Source: The Hebrew University of Jerusalem
Copyright: Medical News TodayThe research was conducted in the laboratory led by Nissm Benvenisty, Dr. Herbert Cohn of Cancer Research at the Silberman Institute of Life Sciences at the Hebrew University of Jerusalem, has shown that iPS cells also undergo abnormal chromosomal changes in the culture .

‘Our results show that human iPS cells are not stable in culture, as previously thought, and request a review of chromosome structure of these cells,’ said Prof. Benvenisty. ‘Moreover, our work shows for the first time the changes in gene expression that accompany these chromosomal aberrations in the culture, paving the way to an understanding of the mechanism by which these early changes occur.

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Prof. Benvenisty, with his post-doctoral Mayshar Yoav Uri and his PhD student Ben-David, has developed a new analytical method to determine the genetic structure of chromosomes in the iPS cells by determining the mode of expression of cellular genes.

Embryonic stem cells, which are undifferentiated cells that have the potential to develop into all cell types of the adult body, and thousands of researchers around the world are working to develop techniques that will allow their potential applications.

For stem cells to be used clinically, however, must be raised in cultures for long periods. During this period, it was observed that embryonic stem cells suffered chromosomal changes, which included changes that characterize the growth of cancerous tumors.

Researchers examined more than 100 cell lines that were published by 18 different laboratories around the world, as well as iPS cultures raised in their laboratories, and thus were able to check a large number of well-chromosome changes in cell lines so far were considered normal.

Each cell is typically two copies of each chromosome in the genome. The researchers found that the Hebrew University, over time, three copies of chromosomes began to appear in the culture, and cells with chromosome could quickly master the other, normal cells in culture. These trisomies are present in the development of abnormal tissue, including cancerous tumors.

According to Prof. It ’s relatively easy to use and allows you to see the changes without having to directly analyze the DNA of cells.

‘The discovery is patented by Yissum, the technology transfer company of the Hebrew University of Jerusalem, which is currently seeking marketing partners for research and development .