‘The prevalence of autism spectrum disorders has increased in recent years,’ the authors write as background information in the article. ‘Use of antidepressants during pregnancy also shows an increase in recent decades, centuries, causing concern that prenatal exposure may contribute to an increased risk of ASD.’To determine whether prenatal exposure to antidepressants, including selective serotonin reuptake inhibitors is associated with an increase of the TSA, Lisa A. Croen, PhD, Kaiser Permanente Northern California, Oakland, and colleagues examined the medical records for children in the study of autism perinatal conducted by Kaiser Permanente Medical Care Program in northern California. The authors included 298 children with ASD and their mothers and 1507 control children and their mothers in the study.

Much of the bad vascular remodeling that occurs in the results of diabetes levels of activation of matrix metalloproteinases MMP glucose or. They break things and allow the cells to move to change the shape of blood vessels, said Ergul. They also destroy the basement membrane of blood vessels, allowing the destructive bleeding that often follows a diabetic stroke. On the positive side, MMPs help clean up the damage to allow repair and recovery

‘Although the number of children exposed before birth to selective serotonin reuptake inhibitors in this population was low, the results suggest that exposure, especially during the first quarter, modestly increases the risk of ASD,’ concluded the the authors. ‘We recommend that our preliminary results are considered and treated with caution, pending the results of further studies to address the complex issue of whether prenatal exposure to SSRIs may be causally related to later diagnosis, ASD in the offspring.’

Furthermore, after adjustment for a history of depression during the first year of delivery, exposure to SSRIs in the first quarter were significantly associated with risk of ASD, as a history of exposure to SSRIs at any time during the delivery of the previous year.

In contrast, no association was observed between the risk of ASD and the indication for treatment for the year before delivery.