The research was funded by the Sloan Foundation and the Ludwig Institute for Cancer Research, which was a partner at Cornell since 1999 to work in the laboratory to clinical trials. The research is reported in the online edition of February 15 of the journal Nanotechnology.In a summary of research presented at the 32nd Annual Heart Rhythm Society Scientific Session at the Moscone Center in San Francisco, author of the study Peyman N. Azadani, MD, research associate at the UCSF Department of Medicine, Division of Cardiac Electrophysiology, and author of Byron K. Lee, MD, associate professor of medicine at the Division of Cardiology at UCSF, began to measure the accuracy of 50 published studies on the potential dangers of the use of Taser products. Lee leads the electrophysiology laboratories and clinics of the Division of Cardiology at UCSF, and the first published study on the security forces use stun guns legal in 2009
The goal, said the lead author and graduate student biomedical Dickson Kirui, is to improve the technology and make it suitable for testing in a clinical trial in humans. Researchers are currently working on a similar prostate cancer cells.
Directed by Carl Batt, Liberty Hyde Bailey Professor of Food Science, researchers have synthesized nanoparticles – what looked like a dumbbell – gold sandwiched between two pieces of iron oxide. They then set antibody that targets a molecule found only in tumor cells of colorectal cancer, for the particles. Once bound, the nanoparticles are swallowed up by the tumor cells.
Once absorbed by the gold particles by the researchers, cancer cells are destroyed by heat – a few degrees above the normal body temperature – while the surrounding tissue remains unharmed. What a low-power laser has no effect on surrounding cells, because this particular wavelength does not heat the cells, if they are not loaded with nanoparticles, the researchers said.
Another weapon in the arsenal against cancer, the nanoparticles are able to identify, target and kill specific cancer cells, leaving normal cells unharmed.
‘If, down the line, you can simply clinically target cancer cells, could then be detached from the surrounding healthy cells from being harmed – that’s the main thing,’ said Kirui.
Gold has potential as a hardware key to the fight against cancer therapies in the future intelligent. It is biocompatible, inert and relatively easy to modify chemically.
Changing the size and shape of gold particles, Kirui and colleagues can enable them to respond to different wavelengths of energy.