The purpose of the survey was to find a way to prevent a bad situation from getting worse in the case of old muscle is injured or not used, said Ronald Cohn, MD, assistant professor of pediatrics and neurology at the ‘McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine. As happy as we were to see that in mice treated with losartan had a positive effect on muscle regeneration, we were very surprised and excited for its prevention atrophy amazing. When we saw that the loss of muscle fibers was completely prevented by losartan treatment, it was pretty amazing, says Cohn.
Previous studies by other groups have shown that aging in humans causes the activity of a protein secreted by cells called transforming growth factor beta increase, and this means more TGF-b in less muscle repair. In addition, studies in mouse models of Marfan syndrome and Duchenne muscular disorders involving the two muscles and connective tissue have revealed that losartan promotes muscle regeneration by blocking a specific protein receptor and, Finally, ramming the activity of TGF-b
Among the data reported today the results were the results of secondary endpoint in the poster Humphrey perimetry 10-2 # 4994/A418 entitled retinitis pigmentosa patient assessment phase 2 study of UF-021:
To investigate the role of losartan in the regeneration of muscle injury in the context of aging, the Hopkins team worked with 40 mice at 21 months were considered geriatric. After treating half of these animals for a week to water laced with losartan, they injected a chemical toxin in the shin muscles all animals. The researchers examined the stained muscle tissue under a microscope at four days and again at 19 days, looking for signs of regeneration: small fibers with larger than normal nuclei. However, after 19 days, mice treated with losartan were about 10 or 15 % of the formation of scar tissue, compared to 30 to 40 per cent of the formation of scar tissue in non- treated.
Using aged mice, a group of researchers at Johns Hopkins University found that losartan, blood pressure, a drug commonly used, not only improves the regeneration of injured muscle, but also protects against the decline of inactivity.
Once again, with 21 months of mice, half treated with losartan and a half, this time the team does not cut the right foot back into mice knee, shin to immobilize the muscles, otherwise, the mice are normally active.
A report on the new role of former drug addicts, who led the preparations for a clinical trial of losartan in older adults, appears online May 11 in the journal Science Translational Medicine.
Muscle loss and weakness during aging a condition known as sarcopenia has not been aggressively addressed by researchers and clinicians of bone loss as a. There are tests and drugs for osteoporosis, muscle wasting, but it is difficult to measure and its effects can be subtle, according to Jeremy D.
Walston, MD Raymond and Anna Lublin Professor of Geriatric Medicine, Johns Hopkins University School of Medicine.